Search results for "Invariant chain"

showing 2 items of 2 documents

Analysis of Invariant Chain Processing in 3 Day Cultured Rat Langerhans Cells

1995

MHC class II molecules, critical peptide binding elements involved in the presentation of exogenous antigen to T helper cells, are expressed constitutively by Langerhans cells (LC) within their epidermal microenvironment. Several studies in mouse and man demonstrated, that short term in vitro culture of LC entails remarkable functional and penotypic alterations, including a profound increase of class II elements exposed at the LC’s surface1. Biosynthetic analysis revealed a downregulation of class II synthesis during the culture period2,3. In recent work on rat LC we described the uncoupling of the coordinately regulated biosynthesis of class II and invariant chain proteins in the course of…

chemistry.chemical_compoundMHC class IIbiologyBiosynthesischemistryExogenous antigenDownregulation and upregulationbiology.proteinPeptide bindingMajor histocompatibility complexIn vitroCell biologyInvariant chain
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Modulation of MHC Class II Determinants on Rat Langerhans Cells During Short Term Culture

1993

Epidermal Langerhans cells (LC) are regarded as the most peripheral outpost of the immune system. They play a pivotal role during the onset of an immune response in the skin. One of the principal functions of LC is reflected in their extraordinary potency to present antigen to high activation requiring naive T cells.

MHC class IIImmune systemintegumentary systemAntigenImmunologybiology.proteinPotencyHigh activationBiologyInvariant chain
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